Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India
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چکیده
منابع مشابه
Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis
BACKGROUND Many studies have been published on the association between single nucleotide polymorphisms (SNP) near the IL28B gene and response to the combined treatments of pegylated-interferon (PegIFN) and ribavirin (RBV) in chronic HCV-infected patients, but without identical conclusions. The aim of this study was to assess impact of the IL28B polymorphisms on the effect of HCV standard treatm...
متن کاملImportance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.
BACKGROUND & AIMS Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected patients. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown. METHODS In patients with chronic hepati...
متن کاملassociation of il28b polymorphisms with the response to peginterferon plus ribavirin combined therapy in polish patients infected with hcv genotype 1 and 4
background three single nucleotide polymorphisms (snps) near interleukin-28b (il-28b) gene were shown to be highly associated with treatment response (svr) in patients with chronic hepatitis c virus (hcv) infection. there is limited data about the role of single and combined il-28b polymorphisms in hcv-infected polish population. objectives this study's aim was to determine predictability of th...
متن کاملRelation of interleukin-1β gene to treatment response in chronic patients infected with HCV genotype 4.
INTRODUCTION Hepatitis C virus (HCV) infection results in chronic hepatitis in more than 70% of infected patients, while 20-30% of patients recover spontaneously. This strengthens the role of the host genetic factors in either spontaneous or drug-induced viral clearance. The aim of this study was to investigate the relationship between interleukin-1β +3953 gene polymorphism and the response to ...
متن کاملIFNL3 (IL28B) and IFNL4 polymorphisms are associated with treatment response in Thai patients infected with HCV genotype 1, but not with genotypes 3 and 6.
Recent studies have shown an association between single nucleotide polymorphisms (SNPs) in the interferon lambda-3 (IFNL3 or IL-28B) and IFNL4 genes and treatment response to hepatitis C virus genotype 1 (HCV-1) infection. The importance of these SNPs for HCV genotype 3 (HCV-3), and particularly HCV genotype 6 (HCV-6), remains to be elucidated. We analyzed a cohort of 225 Thai individuals with ...
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ژورنال
عنوان ژورنال: Tropical Gastroenterology
سال: 2014
ISSN: 0250-636X
DOI: 10.7869/tg.187